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      许 菲

    • 性别:
    • 出生年月:1978年10月
    • 职称、职务:教授、博士生导师
    • 电话:
    • 电子邮箱:feixu@jiangnan.edu.cn

    【学习科研经历】

    1996-2000,武汉大学生物学基地班,学士,

    2000-2007,美国罗格斯大学生物化学,博士

    2003-2006,美国罗格斯大学食品科学,硕士

    2007-2013,美国罗格斯大学生物技术与医药中心,博士后

    2013-2014,美国罗格斯大学生物技术与医药中心,助理研究员

    2015-至今,江南大学,教授

    【研究领域】

    以计算设计和实验验证的交叉学科的方法来获得一定性质与功能的生物大分子

    (1)设计纤维蛋白生物材料

    (2)研究纤维蛋白分子柔性

    (3)改造工业酶制剂

    【主要论著】(著作和论文)

    [1]. Fei Xu, Khan, I. J., McGuinness, K., Parmar, A. S., Silva, T., Murthy, S., Nanda, V., Self-assembly of left and right-handed molecular screws, Journal of American Chemical Society, 2013, 135: 18762-18765

    [2]. Fei Xu, Silva, T., Joshi, M., Zahid, S., Nanda, V., Circular Permutation Directs Orthogonal Assembly in Complex Collagen Peptide Mixtures, Journal of Biological Chemistry, 2013, 288: 31616-31623

    [3]. Sumana, G., Xu, Fei, Nanda, V., Sequence Recombination Improves Target Specificity in a Redesigned Collagen Peptide abc-type Heterotrimer, Proteins: Structure, Function and Bioinformatics, 2013, 81(3): 386-393

    [4]. Grzyb, J., Xu, Fei., ?uczkowska, R., Nanda, V., Reijersee, E., Lubitz, W., Noy, D., Empirical and computational design of iron-sulfur cluster proteins, Biochimi. Biophys. Acta – Bioenergetics, 2012, 1817: 1256-1262

    [5]. Xu, Fei, Li, J., Jain, V., Tu, R., Huang, Q., Nanda, V., Compositionally Controlled Collagen Peptide Self-Assembly and Fiber Morphology, Journal of American Chemical Society, 2012, 134(1):47-50

    [6]. Xu, Fei, Zahid, S., Silva, T., Nanda, V., Computational Design of a Collagen A:B:C-type Heterotrimer, Journal of American Chemical Society, 2011, 133:15260-15263

    [7]. Braun, P., Goldberg, E., Negron, C.,  von Jan, M., Xu, Fei, Nanda, V., Koder, R., and Dror, N., Design Principles for Chlorophyll Binding Sites in Helical Proteins Proteins: Structure, Function, and Bioinformatics, 2011, 79:463-476

    [8]. Xu, Fei, Colasanti, A., Li, Y., Olson, W. K., Long-range effects of histone point mutations on DNA remodeling revealed from computational analyses of SIN-mutant nucleosome structures, Nucleic Acids Research, 2010, 38:6872-82

    [9]. Xu, Fei, Zhang, L., Koder, R., and Nanda, V., De novo self-assembling collagen heterotrimers using explicit positive and negative design. Biochemistry. 2010, 49, 2307-2316

    [10]. Xu, Fei, and Olson, W. K., DNA architecture, deformability, and nucleosome positioning. Journal of Biomolecular Structure and Dynamics. 2010, 27(6), 725-739

    [11]. Grzybe, J., Xu, Fei, Weiner, L., Reigjerse, E., Lubits, W., Nanda, V., Dror, N. De novo design of a non-natural fold for an Iron-sulfur protein: an alpha-helical coiled-coil with a four-iron four-sulfur cluster binding site in its central core. Biochim. Biophys. Acta. 2010, 1797(3):406-413

    [12]. Balasubramanian, S., Xu, Fei, and Olson, W. K., DNA Sequence-directed Organization of Chromation: Structure-based computational analysis of nucleosome-binding sequences. Biophysical Journal, 2009, 96:2245-60

    [13]. Nanda, Vikas, Zahid, Sohail, Xu, Fei, Levine, Daniel, Computational design of intermolecular stability and specificity in protein self-assembly. Methods in Enzymology, 2011, 487:575-593

    [14]. Zhurkin, Victor B., Tolstorukov, Michael Y., Xu, Fei, Colasanti, Andrew V., and Olson, Wilma K., “Sequence-dependent variability of B DNA: an update on bending and curvature,” in DNA conformation and transcription, Takashi Ohyama, Ed., Landes Bioscience/Eurekah.com, Georgetown, TX (2005)

    [15]. Nanda, Vikas, Xu, Fei, Hsieh, Daniel, Chapter 18: Modulation of intrinsic protein properties by computational design - Protein Engineering and Design 2010, CRC Press

    【在读硕、博士人数】

    欢迎有志于计算与实验交叉学科研究的研究生报考

    【以上资料更新日期】

    2015年3月