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      藤田盛久

    • 性别:
    • 出生年月:1979年5月4日
    • 职称、职务:教授
    • 电话:
    • 电子邮箱:fujita@jiangnan.edu.cn

    学术简介

    教育背景:

    2004-2006 日本 筑波大学 生命環境科学研究科 获博士学位

    2002-2004 日本 筑波大学 生命環境科学研究科 获硕士学位

    1998-2002 日本 筑波大学 第二学群 生物資源学類 获学士学位

    工作经历

    2014-现在 江南大学 生物工程学院 教授

    2012-2014 日本 大阪大学 微生物病研究所 助理教授

    2008-2012 日本 大阪大学 微生物病研究所 特任助理教授

    2007-2008 日本 大阪大学 微生物病研究所 博士后

    2006-2007 瑞士 日内瓦大学 生物化学学院 博士后

    2006-2006日本 产业技术综合研究所 糖锁研究中心 博士后

    【研究领域】

    多年来,藤田盛久博士致力于细胞分子生物学和生物化学的研究,尤其是糖生物学和分子遗传学领域。特别是他在蛋白质糖脂翻译后修饰术语也叫做GPI锚定化的生理功能研究中的突出贡献。他鉴定出并分析了GPI锚结构重构中的关键基因。目前,他把目标放在具有生物学和医学意义的重要糖蛋白胞内转运过程的研究。为了深入了解该过程,运用遗传学方法,细胞生物学和生物化学等技术综合的在动物细胞和酵母细胞中开展研究。

    【主要论著】(著作和论文)

    Original Papers

    1.    Theiler, R., Fujita, M., Nagae, M., Yamaguchi, Y., Maeda, Y., and Kinoshita, T. :

    The α-Helical Region in p24γ2 Subunit of p24 Protein Cargo Receptor Is Pivotal for the Recognition and Transport of Glycosylphosphatidylinositol-anchored Proteins.

    J. Biol. Chem., 289:16835-16843 (2014)

    2.    Hirata, T., Fujita, M., Kanazawa, N., Murakami, Y., Maeda, Y., and Kinoshita, T. :

    Glycosylphosphatidylinositol mannosyltransferase II is the rate-limiting enzyme in glycosylphosphatidylinositol biosynthesis under limited dolichol-phosphate mannose availability.

    J. Biochem., 154: 257-264 (2013)

    3.    Kanzawa, N., Shimozawa, N., Wanders, R.J., Ikeda, K., Murakami, Y., Waterham, H.R., Mukai, S., Fujita, M., Maeda, Y., Taguchi, R., Fujiki, Y., and Kinoshita, T. :

    Defective lipid remodeling of GPI anchors in peroxisomal disorders, Zellweger syndrome, and rhizomelic chondrodysplasia punctata.

    J. Lipid Res., 53:653-663 (2012)

    4.    Fujita, M., Watanabe, R., Jaensch, N., Romanova-Michaelides, M., Satoh, T., Kato, M., Riezman, H., Yamaguchi, Y., Maeda, Y., and Kinoshita, T.:

    Sorting of GPI-anchored proteins into ER exit sites by p24 proteins is dependent on remodeled GPI.,

    J. Cell Biol., 194: 61-75 (2011)

    5.    Nakano, Y., Fujita, M., Ogino, K., Kinoshita, T., Oda, Y., and Hirata, H.:

    Biogenesis of GPI-anchored proteins is essential for surface expression of sodium channels in zebrafish Rohon-Beard neurons to respond to mechanosensory stimulation.,

    Development, 137: 1689-1698 (2010)

    6.    Adachi, A., Kano, F., Tsuboi, T., Fujita, M., Maeda, Y., and Murata, M.:

    Golgi-associated GSK3{beta} regulates the sorting process of post-Golgi membrane trafficking.,

    J. Cell Sci., 123: 3215-3225 (2010)

    7.    Fujita, M., Maeda, Y., Ra, M., Yamaguchi, Y., Taguchi, R., and Kinoshita, T.:

    GPI glycan remodeling by PGAP5 regulates transport of GPI-anchored proteins from the endoplasmic reticulum to the Golgi.,

    Cell, 139: 352-365 (2009)

    8.    Hirayama, H., Fujita, M., Yoko-o, Y., and Jigami, Y.:

    O-mannosylation is required for degradation of the endoplasmic reticulum-associated degradation substrate Gas1*p via the ubiquitin/proteasome pathway in Saccharomyces cerevisiae.,

    J. Biochem., 143(4): 555-67 (2008)

    9.    Umemura, M., Fujita, M., Yoko-o, Y., Fukamizu, A., and Jigami, Y.:

    Saccharomyces cerevisiae CWH43 is involved in the remodeling of the lipid moiety of GPI anchors to ceramides.,

    Mol. Biol. Cell, 18(11): 4304-16 (2007)

    10. Maeda, Y., Tashima, Y., Houjou, T., Fujita, M., Yoko-o, T., Jigami, Y., Taguchi, R., and Kinoshita, T.:

    Fatty acid remodeling of GPI-anchored proteins is required for their raft association.,

    Mol. Biol. Cell, 18(4): 1497-506 (2007)

    11. Fujita, M., Umemura, M., Yoko-o, T., and Jigami, Y.:

    PER1 is required for GPI-phospholipase A2 activity and involved in lipid remodeling of GPI-anchored proteins.,

    Mol. Biol. Cell, 17(12): 5253-64 (2006)

    12. Fujita, M., Yoko-o, T., and Jigami, Y.:

    Inositol deacylation by Bst1p is required for the quality control of glycosylphosphatidylinositol-anchored proteins.,

    Mol. Biol. Cell, 17(2): 834-50 (2006)

    13. Fujita, M., Yoko-o, T., Okamoto, M., and Jigami, Y.:

    GPI7 involved in glycosylphosphatidylinositol biosynthesis is essential for yeast cell separation.,

    J. Biol. Chem., 279(50): 51869-79 (2004)

    Reviews and Books

    1.    Kinoshita, T., Maeda, Y. and Fujita, M.:

    Transport of glycosylphosphatidylinositol-anchored proteins from the endoplasmic reticulum.

    Biochim. Biophys. Acta – Mol. Cell Res., in press (2013)

    2.    Fujita, M.:

    Potential Roles of GPI-Anchor Remodeling in Protein Trafficking and Raft Association in Mammalian Cells,

    Trends Glycosci. Glycotech., 24: 244-257 (2012)

    3.    Fujita, M.* and Kinoshita, T. (*corresponding author):

    GPI-anchor remodeling: Potential functions of GPI-anchors in intracellular trafficking and membrane dynamics.,

    Biochim. Biophys. Acta, 1821 (8): 1050-1058 (2012)

    4.    Fujita, M. and Kinoshita, T.:

    Structural remodeling of GPI anchors during biosynthesis and after attachment to proteins.,

    FEBS Lett., 584 (9): 1670-1677 (2010)

    5.    Maeda, Y., Fujita, M., and Kinoshita, T.:

    GPI-Anchor: Update for Biosynthesis and Remodeling,

    Trends Glycosci. Glycotech., 22: 182-193 (2010)

    6.    Kinoshita, T. and Fujita, M.:

    Overview of GPI biosynthesis,

    The Enzymes, Academic Press, 26: 1-30 (2009)

    7.    Kinoshita, T., Fujita, M., and Maeda, Y.:

    Biosynthesis, remodelling and functions of mammalian GPI-anchored proteins: recent progress.,

    J. Biochem., 144(3): 287-94 (2008)

    8.    Fujita, M. and Jigami, Y.:

    Lipid remodeling of GPI-anchored proteins and its function.,

    Biochim. Biophys. Acta, 1780(3): 410-20 (2008)

    【科研项目】

    2014年 江苏省自然科学基金青年基金

    【科研成果及奖励】

    【荣誉与奖励】

    2012 Young Investigator Award of The Japanese Biochemical Society

    2012 Young Investigator Award of The Japanese Society of Carbohydrate Research

    【在读硕、博士人数】

    硕士3名

    【已毕业硕、博士人数】

    【以上资料更新日期】

    2014年6月