石贵阳-正高--

国家级重点学科

一级学科博士学位授予点

“双一流”建设学科

师资队伍
Faculty and staff

李子杰

李子杰

职称:副教授、硕士生导师

学历/学位:研究生、博士

电话:0510-85197071

电子邮箱:lizijie@jiangnan.edu.cn

简介

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长期从事功能糖尤其是稀有糖的合成及功能研究,主要承担糖生物工程、系统生物学与生物合成前沿、分子生物学实验等课程的讲授工作,获校级教学成果二等奖1项。近年来发表高水平研究论文30余篇,影响因子累积超过120;申请发明专利15件,已授权6件,其中国际发明专利1项;主持国家自然科学基金面上/青年项目、中国博士后基金面上项目、山东省重点研发计划子课题、生化工程国家重点实验室开放基金项目、工业生物技术教育部重点实验室开放课题、企业横向课题等项目;江苏省科技副总特聘专家(2022),指导学生获得校级优秀毕业论文,本人获得江南大学本科优秀毕业论文指导教师,江南大学本科生优秀班主任,指导学生参加全国大学生生命科学竞赛获得国家一等奖,指导学生参加生命科学创新创业大赛获得国家二等奖。


学习工作经历

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2003-2007 河北科技大学生物科学与工程学院,生物技术专业,理学学士

2007-2012 山东大学国家糖工程中心,微生物学专业(硕博连读),博士学位

2010-2011 美国俄亥俄州立大学,生化与化学系,博士联合培养

2011-2012 美国佐治亚州立大学,化学系,博士联合培养 

2012-2016 江南大学生物工程学院,校聘副教授

2016-现在 江南大学生物工程学院,糖化学与生物技术教育部重点实验室副教授

2020-现在 江南大学糖化学与生物技术教育部重点实验室副主任


主要成果

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一、论文(论著)发表情况

部分代表性论文如下:

1. Zijie Li*, Linxue Feng, Zhou Chen, Yangfan Hu, Kangqing Fei, Huilin Xu, Xiao-Dong Gao*. Efficient enzymatic synthesis of D-allulose using a novel D-allulose-3-epimerase from Caballeronia insecticola. Journal of the Science of Food and Agriculture. 2022, https://doi.org/10.1002/jsfa.12147

 

2. Zijie Li*, Wanjie Li, Yasen Wang, Zhouchen, Hideki Nakanishi, Xiangyang Xu, Xiao-Dong Gao*. Establishment of a Nowel Cell Surface Display Platform Based on Natural "Chitosan Beads" of Yeast Spores. Journal of Agriculture and Food Chemistry. 2022, 70(24), 7479-7489.

 

3. Zhou Chen, Xiao-Dong Gao, Zijie Li*. Recent advances regarding the physiological functions and biosynthesis of D-allulose. Frontiers in Microbiology. 2022, 13, 881037

 

4. Zhou Chen, Kangqing Fei, Yangfan Hu, Xiangyang Xu, Xiao-Dong Gao, Zijie Li*. Identification of a novel alditol oxidase from Thermopolyspora flexuosa with potential application in D-glyceric acid production. Molecular Biotechnology. 2022, 64(7), 804-813.

 

5. Zijie Li, Xiaoxiao Liu, Hideki Nakanishi, Xiao-Dong Gao*. Encapsulation of mannose-6-phosphate isomerase in yeast spores and its application in L-ribose production. Journal of Agriculture and Food Chemistry. 2020, 68(25), 6892-6899.

 

6. Zijie Li*, Fen Li, Li Cai, Zhou Chen, Ling Qin, Xiao-Dong Gao*. One-pot multienzyme synthesis of rare ketoses from glycerol. Journal of Agriculture and Food Chemistry. 2020, 68(5), 1347-1353.

 

7. Zhou Chen, Zijie Li*, Fen Li, Mayan Wang, Ning Wang, Xiao-Dong Gao*. Cascade synthesis of rare ketoses by whole cells based on L-rhamnulose-1-phosphate aldolase. Enzyme and Microbial Technology. 2020,133:109456.

 

8. Zhou Chen, Zijie Li*, Fen Li, Ning Wang, Xiao-Dong Gao*. Characterization of alditol oxidase from Streptomyces coelicolor and its application in the production of rare sugars. Bioorganic & Medicinal Chemistry. 2020, 28 (10), 115464.

 

9. Xiaoxiao Liu#, Zijie Li#, Zhou Chen, Ning Wang, Yahui Gao, Hideki Nakanishi*, Xiao-Dong Gao*. Production of L-ribulose using an encapsulated L-arabinose isomerase in yeast spores. Journal of Agriculture and Food Chemistry. 2019, 67(17), 4868-4875. (#equal contribution).

10. Shengtao Li, Tiantian Lu, Xinxin Xu, Yi Ding, Zijie Li, Toshihiko Kitajima, Neta Dean, Ning Wang*, Xiao-Dong Gao*. Reconstitution of the lipid-linked oligosaccharide pathway for assembly of high-mannose N-glycans. Nature Communications. 2019, 10(1):1813.

11. Leo D Bemena, Omar Mukama, Aaron M Neiman, Zijie Li, Xiao-Dong Gao*, Hideki Nakanishi*In vitro reconstitution of the yeast spore wall dityrosine layer discloses the mechanism of its assembly. Journal of Biological Chemistry.2017, 292, 15880-15891. 

12. Aimin Li, Li Cai, Zhou Chen, Mayan Wang, Ning Wang, Hideki Nakanishi, Xiao-Dong Gao*, Zijie Li*. Recent advances in the synthesis of rare sugars using DHAP-dependent aldolases. Carbohydrate Research. 2017, 452, 108-115.

 

13. Zijie Li, Xiao-Dong Gao, Li Cai*. Synthesis of Rare Pentoses Using Microbial and Enzymatic Reactions. Current Organic Chemistry. 2016, 20, 1456-1464.

14. Mohui Wei#, Zijie Li#, Tiehai Li, Baolin Wu, Yunpeng Liu, Jingyao Qu, Xu Li, Lei Li, Li Cai, Peng George Wang*. Transforming Flask Reaction into Cell-Based Synthesis: Production of Polyhydroxylated Molecules via Engineered Escherichia coli. ACS Catalysis. 2015, 5, 4060-4065. (#equal contribution)  

15. Zijie Li, Xiaoru Wu , Li Cai , Shenglin Duan , Jia Liu, Peng Yuan, Hideki Nakanishi*, Xiao-Dong  Gao*. Enzymatic Synthesis of Rare Sugars with L-Rhamnulose-1-phosphate Aldolase from Thermotoga maritima MSB8. Bioorganic Medicinal Chemistry Letters, 2015, 25, 3980-3983.

16. Zijie Li, Yi Li, Shenglin Duan, Jia Liu, Peng Yuan, Hideki Nakanishi*, Xiao-Dong Gao*. Bioconversion of D-Glucose to D-Psicose with Immobilized D-Xylose Isomerase and D-Psicose 3-epimerase on Saccharomyces cerevisiae Spores. Journal of Industrial Microbiology and Biotechnology, 2015, 42, 1117-1128.

 

17. Zijie Li, Yingxin Qiao, Li Cai, Hideki Nakanishi*, Xiao-Dong Gao*. Characterization of Glycerol Phosphate Oxidase from Streptococcus pneumoniae and Its Application for Ketose Synthesis. Bioorganic Medicinal Chemistry Letter, 2015, 25, 504-507.

 

18. Zijie Li, Beibei He, Yahui Gao, Li Cai*. Synthesis of D-Sorbose and D-Psicose by Recombinant Escherichia coli. Journal of Carbohydrate Chemistry, 2015, 34(6), 349-357.

 

19. Libing Shi, Zijie Li, Hiroyuki Tachikawa, Xiao-Dong Gao*, Hideki Nakanishi*. Use of Yeast Spores for Microencapsulation of Enzymes. Applied and Environmental Microbiology2014, 80 (15): 4502-4510.

 

20. Zijie Li, Yahui Gao, Hideki Nakanishi, Xiao-Dong Gao*, Li Cai*. Biosynthesis of Rare Hexoses Using Microorganisms and Related Enzymes. Beilstein Journal of Organic Chemistry. 2013, 9, 2434-2445.

 

21. Zijie Li, Li Cai*, Mohui Wei, Peng George Wang*. One-Pot Four-Enzyme Synthesis of Ketoses with class I D-Fructose 1,6-bisphosphate Aldolase from Staphylococcus carnosus and Rabbit Muscle. Carbohydrate Research. 2012, 357, 143-146.

 

22. Zijie Li, Li Cai*, Qingsheng Qi, Peng George Wang*. Enzymatic Synthesis of D-Sorbose and D-Psicose with Aldolase RhaD: Effect of Acceptor Configuration on Enzyme Stereoselectivity. Bioorganic Medicinal Chemistry Letter, 2011, 21, 7081-7084.

 

23. Zijie Li, Li Cai, Qingsheng Qi, Thomas J Styslinger, Guohui Zhao, Peng George Wang*. Synthesis of Rare Sugars with L-fuculose-1-phosphate Aldolase (FucA) from Thermus thermophilus HB8. Bioorganic Medicinal Chemistry Letter, 2011, 21, 5084-5087



二、专利情况

 1、一种以D-甘油醛为受体合成D-山梨糖和D-阿洛酮糖的方法 ZL 202010014710.5

2、一种L型稀有己酮糖的制备方法 ZL202010014721.3

3、一种D型稀有己酮糖的制备方法 ZL202010015442.9

4 L-鼠李树胶糖-1-磷酸醛缩酶及其在催化合成稀有糖D-阿洛酮糖中的应用 ZL201810209627.6

5L-鼠李树胶糖-1-磷酸醛缩酶及其在催化合成稀有糖D-山梨糖中的应用ZL201810209650.5

6、一种以酿酒酵母孢子为载体的新型固定化酶的制备方法 ZL201310422568.8


三、承担教学科研项目情况

1、国家自然科学青年基金(21302069),主持(已结题)

2、中国博士后基金面上项目(2014M551500),主持(已结题)

3、中央高校基本科研业务费(2013-2014),主持(已结题)

4、生化工程国家重点实验室开放基金(2014KF-02),主持(已结题)

5、山东省重点研究计划子课题(在研)

6、国家自然科学面上基金(32171475),主持(在研)

7、企业横向课题:稀少糖产品生物合成技术研发,主持(在研)


四、获奖情况

1、江苏省科技副总(2022

2、生命科学竞赛国家三等奖指导教师(2020

3、生命科学竞赛国家一等奖指导教师(2019

4、生命科学创新创业大赛国家二等奖指导教师(2019

5、江南大学校级教学成果二等奖 2019

6、江南大学本科生优秀班主任 2016

7、江南大学本科优秀毕业论文指导教师(2015

8、糖生物学会议优秀墙报(2014

 

以上资料更新时间截止:20229






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石贵阳-正高--