李子杰

职称：副教授、博士生导师

学历/学位：研究生、博士

电话：0510-85197071

电子邮箱：lizijie@jiangnan.edu.cn

长期从事功能糖特别是稀有糖的合成及功能研究，主要承担糖生物工程、系统生物学与生物合成前沿、细胞生物学等课程的讲授工作，获校级教学成果二等奖1项。近年来发表高水平研究论文40余篇，影响因子累积超过150；授权国家发明专利16件；主持国家自然科学基金面上/青年项目、中国博士后基金面上项目、山东省重点研发计划子课题、生化工程国家重点实验室开放基金项目、工业生物技术教育部重点实验室开放课题、企业横向课题等项目；食品科学技术学报青年编委，江苏省科技副总特聘专家（2022），指导学生获得校级优秀毕业论文，本人获得江南大学本科优秀毕业论文指导教师，江南大学本科生优秀班主任，指导学生获得包括全国大学生生命科学竞赛国家一等奖在内的国家级奖项5项。

2003-2007 河北科技大学生物科学与工程学院，生物技术专业，理学学士

2007-2012 山东大学国家糖工程中心，微生物学专业（硕博连读），博士学位

2010-2011 美国俄亥俄州立大学，生化与化学系，博士联合培养

2011-2012 美国佐治亚州立大学，化学系，博士联合培养 

2012-2016 江南大学生物工程学院，校聘副教授

2016-现在 江南大学生物工程学院，糖化学与生物技术教育部重点实验室副教授

2020-现在 江南大学糖化学与生物技术教育部重点实验室副主任

一、论文（论著）发表情况

代表性期刊论文：

1、Jiawen Bai, Yasen Wang, Wanjie Li, Chenyu Si, Zhouge Lan, Yishi Liu, Hideki Nakanishi, Zijie Li*. Development of a self-assembled dual-enzyme co-display platform on the surface of the natural "chitosan beads" of yeast spores. International Journal of Biological Macromolecules. 2025, 286: 138308.

2、Kangqing Fei, Zhou Chen, Liqun Shen, Xiao-Dong Gao, Hideki Nakanishi, Zijie Li*. Efficient biosynthesis of rare sugars using glycerol as a sole carbon source in metabolic engineered Bacillus subtilis. Food Bioscience. 2025, 64: 105917.

3、Buqing Wang, Xiaoman Zhou, Yasen Wang, Yahui Gao, Hideki Nakanishi, Morihisa Fujita, Zijie Li*. Enhancement of thermostability and expression level of Rasamsonia emersonii lipase in Pichia pastoris and its application in biodiesel production in a continuous flow reactor. International Journal of Biological Macromolecules. 2024, 278: 134481.

4、Zijie Li*, Yangfan Hu, Cheng Yu, Kangqing Fei, Liqun Shen, Yishi Liu, Hideki Nakanishi. Semi-rational engineering of D-allulose 3-epimerase for simultaneously improving the catalytic activity and thermostability based on D-allulose biosensor. Biotechnology Journal. 2024, 19(8): e2400280

5、Buqing Wang, Yasen Wang, Xiaoman Zhou, Xiao-Dong Gao, Morihisa Fujita, Zijie Li*. Highly efficient expression of Rasamsonia emersonii lipase in Pichia pastoris: characterization and gastrointestinal simulated digestion in vitro. Journal of the Science of Food and Agriculture. 2024, 104(9): 5603-5613

6、Hui-Lin Xu, Xiaoman Zhou, Shuai Chen, Si Xu, Zijie Li*, Hideki Nakanishi* and Xiao-Dong Gao*. Rare sugar L-sorbose exerts antitumor activity by impairing glucose metabolism. Communications Biology. 2023, 6, 259.

7、Zijie Li*, Linxue Feng, Zhou Chen, Yangfan Hu, Kangqing Fei, Huilin Xu, Xiao-Dong Gao*. Efficient enzymatic synthesis of D-allulose using a novel D-allulose-3-epimerase from Caballeronia insecticola. Journal of the Science of Food and Agriculture. 2023, 103, 339-348.

8、Yasen Wang, Buqing Wang, Yahui Gao, Hideki Nakanishi, Xiao-Dong Gao, Zijie Li*. Highly efficient expression and secretion of human lysozyme using multiple strategies in Pichia pastoris, Biotechnology Journal. 2023, 18, 2300259.

9、Zijie Li#*, Wanjie Li#, Yasen Wang, Zhou Chen, Hideki Nakanishi, Xiangyang Xu, Xiao-Dong Gao*. Establishment of a novel cell surface display platform based on natural "Chitosan Beads" of yeast spores. Journal of Agricultural and Food Chemistry. 2022, 70(24), 7479-7489 (封面).

10、Zhou Chen, Xiao-Dong Gao, Zijie Li*. Recent advances regarding the physiological functions and biosynthesis of D-allulose. Frontiers in Microbiology. 2022, 13, 881037.

11、Shijie Fu#, Yanting Dang#, Huilin Xu, Aimin Li, Xiaoman Zhou, Xiao-Dong Gao, Zijie Li*. Aloe vera-fermented beverage ameliorates obesity and gut dysbiosis in high-fat-diet mice. Foods. 2022, 11, 3728.

12、Qiang Chao, Tianlu Li, Jixiang Jia, Zijie Li, Peng Peng, Xiao-Dong Gao*, Ning Wang*. Spore-encapsulating glycosyltransferase catalysis tandem reactions: facile chemoenzymatic synthesis of complex human glycans. ACS Catalysis. 2022, 12, 3181-3188.

13、Zhou Chen, Kangqing Fei, Yangfan Hu, Xiangyang Xu, Xiao-Dong Gao, Zijie Li*. Identification of a novel alditol oxidase from Thermopolyspora flexuosa with potential application in D-glyceric acid production. Molecular Biotechnology. 2022, 64(7), 804-813.

14、Zijie Li, Xiaoxiao Liu, Hideki Nakanishi, Xiao-Dong Gao*. Encapsulation of mannose-6-phosphate isomerase in yeast spores and its application in L-ribose production. Journal of Agricultural and Food Chemistry. 2020, 68(25), 6892-6899.

15、Zijie Li*#, Fen Li#, Li Cai, Zhou Chen, Ling Qin, Xiao-Dong Gao*. One-pot multienzyme synthesis of rare ketoses from glycerol. Journal of Agricultural and Food Chemistry. 2020, 68(5), 1347-1353.

16、Zhou Chen, Zijie Li*, Fen Li, Mayan Wang, Ning Wang, Xiao-Dong Gao*. Cascade synthesis of rare ketoses by whole cells based on L-rhamnulose-1-phosphate aldolase. Enzyme and Microbial Technology. 2020,133:109456.

17、Zhou Chen, Zijie Li*, Fen Li, Ning Wang, Xiao-Dong Gao*. Characterization of alditol oxidase from Streptomyces coelicolor and its application in the production of rare sugars. Bioorganic & Medicinal Chemistry. 2020, 28 (10), 115464.

18、Xiaoxiao Liu#, Zijie Li#, Zhou Chen, Ning Wang, Yahui Gao, Hideki Nakanishi*, Xiao-Dong Gao*. Production of L-ribulose using an encapsulated L-arabinose isomerase in yeast spores. Journal of Agricultural and Food Chemistry. 2019, 67(17), 4868-4875(封面).

19、Shengtao Li#, Tiantian Lu#, Xinxin Xu, Yi Ding, Zijie Li, Toshihiko Kitajima, Neta Dean, Ning Wang*, Xiao-Dong Gao*. Reconstitution of the lipid-linked oligosaccharide pathway for assembly of high-mannose N-glycans. Nature Communications. 2019, 10(1):1813

20、Leo D Bemena, Omar Mukama, Aaron M Neiman, Zijie Li, Xiao-Dong Gao*, Hideki Nakanishi* In vitro reconstitution of the yeast spore wall dityrosine layer discloses the mechanism of its assembly. Journal of Biological Chemistry. 2017, 292, 15880-15891

21、Aimin Li, Li Cai, Zhou Chen, Mayan Wang, Ning Wang, Hideki Nakanishi, Xiao-Dong Gao*, Zijie Li*. Recent advances in the synthesis of rare sugars using DHAP-dependent aldolases. Carbohydrate Research. 2017, 452, 108-115.

22、Zijie Li, Xiao-Dong Gao, Li Cai*. Synthesis of rare pentoses using microbial and enzymatic reactions. Current Organic Chemistry. 2016, 20, 1456-1464.

23、Mohui Wei#, Zijie Li#, Tiehai Li, Baolin Wu, Yunpeng Liu, Jingyao Qu, Xu Li, Lei Li, Li Cai, Peng George Wang*. Transforming flask reaction into cell-based synthesis: production of polyhydroxylated molecules via engineered Escherichia coli. ACS Catalysis. 2015, 5, 4060-4065.

24、Zijie Li#, Xiaoru Wu#, Li Cai, Shenglin Duan, Jia Liu, Peng Yuan, Hideki Nakanishi*, Xiao-Dong Gao*. Enzymatic synthesis of rare sugars with L-rhamnulose-1-phosphate aldolase from Thermotoga maritima MSB8. Bioorganic Medicinal Chemistry Letters. 2015, 25, 3980-3983.

25、Zijie Li#, Yi Li#, Shenglin Duan, Jia Liu, Peng Yuan, Hideki Nakanishi*, Xiao-Dong Gao*. Bioconversion of D-glucose to D-psicose with immobilized D-xylose isomerase and D-psicose 3-epimerase on Saccharomyces cerevisiae spores. Journal of Industrial Microbiology and Biotechnology. 2015, 42, 1117-1128.

26、Zijie Li, Yingxin Qiao, Li Cai, Hideki Nakanishi*, Xiao-Dong Gao*. Characterization of glycerol phosphate oxidase from Streptococcus pneumoniae and its application for ketose synthesis. Bioorganic Medicinal Chemistry Letter. 2015, 25, 504-507.

27、Zijie Li, Beibei He, Yahui Gao, Li Cai*. Synthesis of D-sorbose and D-psicose by recombinant Escherichia coli. Journal of Carbohydrate Chemistry. 2015, 34(6), 349-357.

28、Libing Shi, Zijie Li, Hiroyuki Tachikawa, Xiao-Dong Gao*, Hideki Nakanishi*. Use of yeast spores for microencapsulation of enzymes. Applied and Environmental Microbiology. 2014, 80 (15): 4502-4510.

29、Zijie Li, Yahui Gao, Hideki Nakanishi, Xiao-Dong Gao*, Li Cai*. Biosynthesis of rare hexoses using microorganisms and related enzymes. Beilstein Journal of Organic Chemistry. 2013, 9, 2434-2445.

30、Zijie Li, Li Cai*, Mohui Wei, Peng George Wang*. One-pot four-enzyme synthesis of ketoses with class I D-fructose 1,6-bisphosphate aldolase from Staphylococcus carnosus and rabbit muscle. Carbohydrate Research. 2012, 357, 143-146.

31、Zijie Li, Li Cai*, Qingsheng Qi, Peng George Wang*. Enzymatic synthesis of D-sorbose and D-psicose with aldolase RhaD: Effect of acceptor configuration on enzyme stereoselectivity. Bioorganic Medicinal Chemistry Letter. 2011, 21, 7081-7084.

32、Zijie Li#, Li Cai#, Qingsheng Qi, Thomas J Styslinger, Guohui Zhao, Peng George Wang*. Synthesis of rare sugars with L-fuculose-1-phosphate aldolase (FucA) from Thermus thermophilus HB8. Bioorganic Medicinal Chemistry Letter, 2011, 21, 5084-5087.

33、李子杰*，沈立群，费康清，陈洲，中西秀树. D-塔格糖的生理活性及生物合成研究进展，食品科学技术学报，2023, 6, 20-28.

34、胡扬帆，王雨露，费康清，俞姝瑶，高雅慧，李子杰*. 枯草芽孢杆菌全细胞转化高效合成D-阿洛酮糖，食品科学技术学报，2023, 5, 76-84（获该刊2024年度最具影响力论文奖）.

35、李婉杰，王亚森，陈洲，中西秀树，许向阳，高晓冬，李子杰*. 基于壳聚糖结合模块构建新型酿酒酵母孢子表面展示系统. 微生物学报，2022, 62, 4431-4446.

二、专利情况

主要授权发明专利：

1、一种高温度稳定性的D-阿洛酮糖3-差向异构酶突变体酶及其应用， ZL202310467685.X

2、一种D-阿洛酮糖3-差向异构酶突变体及其应用, ZL202310467686.4

3、一种壳聚糖亲和蛋白、酶的固定化方法及生物材料，ZL202210519254.9

4、一种壳聚糖结合域氨基酸序列的应用及酿酒酵母孢子固定化酶的方法, ZL202210519240.7

5、一种L型稀有己酮糖的制备方法, ZL202010014721.3

6、一种D型稀有己酮糖的制备方法，ZL202010015442.9

7、L-山梨糖在制备治疗肿瘤的药物中的应用，ZL202110463305.6

8、一种以D-甘油醛为受体合成D-山梨糖和D-阿酮糖的方法, ZL202010014710.5

9、L-鼠李树胶糖-1-磷酸醛缩酶及其在催化合成稀有糖D-阿洛酮糖中的应用, ZL201810209627.6

10、L-鼠李树胶糖-1-磷酸醛缩酶及其在催化合成稀有糖D-山梨糖中的应用,            ZL201810209650.5

三、承担教学科研项目情况

1、国家自然科学青年基金（21302069），主持（已结题）

2、中国博士后基金面上项目（2014M551500），主持（已结题）

3、生化工程国家重点实验室开放基金（2014KF-02），主持（已结题）

4、山东省重点研究计划子课题（已结题）

5、国家自然科学面上基金（32171475），主持（在研）

6、企业横向课题：稀少糖产品生物合成技术研发，主持（在研）

7、企业横向课题：高端抗衰口服产品抗氧化/抗衰老功能评价，主持（在研）

四、获奖情况

1、食品科学技术学报青年编委（2023-）

2、江苏省科技副总（2022）

3、生命科学竞赛国家三等奖指导教师（2024、2023、2020）

4、生命科学竞赛国家一等奖指导教师（2019）

5、生命科学创新创业大赛国家二等奖指导教师（2019）

6、江南大学校级教学成果二等奖 （2019）

7、江南大学本科生优秀班主任 （2016）

8、江南大学本科优秀毕业论文指导教师（2015）

9、糖生物学会议优秀墙报（2014）

以上资料更新时间截止：2025年3月