夏媛媛
夏媛媛
职称:副研究员
学历/学位:研究生/博士
电话:15261599317
电子邮箱:yyxia@jiangnan.edu.cn
长期从事酶工程与合成生物学的研究,主要承担微生物学、理科综合实验等课程的讲授工作。近年来以第一作者发表研究性论文7篇,参与出版英文专著1部;申请发明专利39项,其中授权国际专利2项,授权国内专利11项;主持国家自然科学基金青年基金1项,主持中国博士后科学基金1项,主持国家重点研发子课题一项,参与国家自然科学基金省部级科研项目2项,主持横向3项;指导本科生参与学科竞赛,获得2020国际基因工程机器大赛(iGEM)金奖,获得2022全国大学生生命科学竞赛三等奖。 |
2009.9 – 2012.6 江南大学,生命科学与技术人才培养基地强化班,工科学士 2024.7 – 至今 江南大学,生物工程学院,助理研究员 其中: |
一、论文(论著)发表情况 | |||
1.Xia, Yuanyuan, et al. "Discovery of the ATPase Activity of a Cobalt-Type Nitrile Hydratase Activator and Its Promoting Effect on Enzyme Maturation." Biochemistry 61.24 (2022): 2940-2947. 2.Xia, Yuanyuan, et al. "Tailoring the Hinge Residue at the Substrate Access Tunnel Entrance Improves the Catalytic Performance of Industrialized Nitrile Hydratase Toward 3‐Cyanopyridine." ChemistrySelect 7.34 (2022): e202201941. 3.Xia, Yuanyuan, et al. "Significant Improvement of Both Catalytic Efficiency and Stability of Fructosyltransferase from Aspergillus niger by Structure-Guided Engineering of Key Residues in the Conserved Sequence of the Catalytic Domain." Journal of Agricultural and Food Chemistry 70.23 (2022): 7202-7210. 4.Xia, Yuanyuan, et al. "Development of thermostable sucrose phosphorylase by semi-rational design for efficient biosynthesis of alpha-D-glucosylglycerol." Applied Microbiology and Biotechnology 105 (2021): 7309-7319. 5.Xia, Yuanyuan, et al. "Metallochaperone function of the self‐subunit swapping chaperone involved in the maturation of subunit‐fused cobalt‐type nitrile hydratase." Biotechnology and Bioengineering 116.3 (2019): 481-489. 6.Xia, Yuanyuan, et al. "Improving the thermostability and catalytic efficiency of the subunit‐fused nitrile hydratase by semi‐rational engineering." ChemCatChem 10.6 (2018): 1370-1375. 7.Xia, Yuanyuan, et al. "Construction of a subunit-fusion nitrile hydratase and discovery of an innovative metal ion transfer pattern." Scientific Reports 6.1 (2016): 19183. |
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二、专利情况 | |||
1.Fused NHase with improved specific activity and stability. U.S. Patent. US9896679B2(授权) 2.Fused NHase with improved specific activity and stability. U.S. Patent. US9670474B2 (授权) 3.一种比酶活和稳定性提高的融合型腈水合酶,CN104862296B(授权) 4.一种比酶活和稳定性提高的融合型腈水合酶,CN104774829B(授权) 5.一种生产羟基酪醇的重组大肠杆菌及其应用,CN2021101760030(授权) 6.一株缩短发酵周期的产酪醇重组大肠杆菌及其应用,CN202110598376.7(授权) 7.一种熊蜂生假丝酵母强组成型启动子及其应用,CN202011156814.6(授权) 8.一种提高酿酒酵母工程菌脂肪酸乙酯产量的方法,CN2021100898359(授权) 9.一种产蔗糖磷酸化酶突变体及其应用,CN2020105068951(授权) |
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三、承担教学科研项目情况 | |||
1.主持国家自然科学基金青年基金1项,亚基融合型腈水合酶钴离子摄取机制解析(32001064),24万元,在研; 2.主持中国博士后科学基金1项,新型亚基融合型腈水合酶成熟机制解析(2020M671331),8万元,结题; 3.主持国家重点研发子课题一项,工业酶活性中心突变体催化效率测定(2021YFC2100102-03),50万元,在研; 4.主持横向3项,总经费29.5万元; 5.参与国家自然科学基金省部级科研项目2项,在研。 |
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四、获奖情况(含指导学生获奖) | |||
1.2020国际基因工程机器大赛(iGEM),金奖,1/25; 2.全国大学生生命科学竞赛(2022,科学探究类)江苏赛区,三等奖,1/2。 |