石贵阳-正高--

国家级重点学科

一级学科博士学位授予点

“双一流”建设学科

师资队伍
Faculty and staff

邓禹

邓禹

职称:教授、博士生导师

学历/学位:研究生/博士

电话:13665117395

电子邮箱:dengyu@jiangnan.edu.cn

简介

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长期从事发酵工程,代谢工程,合成生物学,工业微生物等领域的研究,主要承担《细胞生物学》等课程的讲授工作。发表高水平论文30余篇,申请发明专利33余项,其中授权11项;主持包括国家重点研发计划、国家自然基金等在内的国家及省部级科研项目10余项;获得江苏省特聘教授、 江苏省“双创人才”、江苏双创团队负责人、江苏省“六大人才高峰”、无锡市社会事业领军人才等荣誉称号。

学习工作经历

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2001-2005 江南大学,生物工程专业,工学学士

2005-2007 江南大学,生物工程学院, 发酵工程专业, 工学硕士

2007-2011 美国弗吉尼亚联邦大学,化学与生命科学工程专业,工学博士

2011-2013 美国达特茅斯学院,博士后研究员

2013-2014 美国堪萨斯州立大学,助理教授

2015-至今 江南大学粮食发酵工艺与技术国家工程实验室,教授

主要成果

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一、论文(论著)发表情况

   部分代表性论文如下:

  1. Xue Sui, Mei Zhao, Yingli Liu, Jing Wang, Guohui Li*, Xiaojuan Zhang*, Yu Deng*. Enhancing glutaric acid production in Escherichia coli by uptake of malonic acid. Journal of Industrial Microbiology & Biotechnology. 2020. DOI:10.1007/s10295-020-02268-6 (IF=2.993).

  2. Yunying Zhao, Weiqing Lu, Yingli Liu, Jing Wang, Shenghu Zhou, Yin Mao, Guohui Li, Yu Deng*. Efficient total nitrogen removal from wastewater by Paracoccus denitrificans DYTN-1. Letters in Applied Microbiology. 2020, 70(4):263-273. (IF=1.805).

  3. Yunying Zhao, Chunlei Cao, Yingli Liu, Jing Wang, Shiyun Li, Jie Li, Yu Deng*. Genetic analysis of oxidative and endoplasmic reticulum stress responses induced by cobalt toxicity in budding yeast. Biochimica et Biophysica Acta-General Subjects. 2020, 1864(3):129516. (IF=3.681).

  4. Yunying Zhao, Chunlei Cao, Yingli Liu, Jing Wang, Jie Li, Shiyun Li, Yu Deng*. Identification of the genetic requirements for zinc tolerance and toxicity in Saccharomyces cerevisiae. G3: Genes, Genomes, Genetics. 2020. 10 : 479-488. (IF=2.63).

  5. Guohui Li, Dixuan Huang, Xue Sui, Shiyun Li, Bing Huang, Xiao-Juan Zhang, Hui Wu, Yu Deng*. Advances in biological production of medium-chain dicarboxylic acids for nylon materials. Reaction Chemistry & Engineering. 2019. 5, 221 - 238. (IF=3.935).

  6. Yuqing Tian, Yu Deng*, Wenli Zhang*, Wanmeng Mu. Sucrose isomers as alternative sweeteners: properties, production, and applications. Applied Microbiology and Biotechnology. 2019,103(21-22):8677-8687. (IF=3.67).

  7. Hao Wu, Jiawei Huang, Yu Deng*, Wenli Zhang*, Wanmeng Mu. Production of L-ribose from L-arabinose by co-expression of L-arabinose isomerase and D-lyxose isomerase in Escherichia coli. Enzyme and Microbial Technology. 2020, 132:109443. (IF= 3.553)

  8. Liying Ruan, Lu Li, Dian Zou, Cong Jiang, Zhiyou Wen, Shouwen Chen, Yu Deng*, Xuetuan Wei*. Metabolic engineering of Bacillus amyloliquefaciens for enhanced production of S-adenosylmethionine by coupling of an engineered S-adenosylmethionine pathway and the tricarboxylic acid cycle. Biotechnology for Biofuels. 2019, 12:211. (IF=5.497).

  9. Kangjia Zhu, Guohui Li, Ren Wei, Yin Mao, Yunying Zhao, Aiyong He, Zhonghu Bai, Yu Deng*. Systematic analysis of the effects of different nitrogen source and ICDH knockout on glycolate synthesis in Escherichia coli. Journal of Biological Engineering, 2019, 13 (1), 30 (IF= 2.667)

  10. Ju Yang, Yiting Lu, Yunying Zhao, Zhonghu Bai, Zheng Ma, Yu Deng*. Site-directed mutation to improve the enzymatic activity of 5-carboxy-2-pentenoyl-CoA reductase for enhancing adipic acid biosynthesis. Enzyme and Microbial Technology, 2019, 125, 6-12 (IF= 3.553)

  11. Mei Zhao, Guohui Li, Yu Deng*. Engineering Escherichia coli for glutarate production as the C5 platform backbone. Applied and Environmental Microbiology, 2018, 84:e00814-18. (IF= 4.077).

  12. Na Chen, Jingya Wang, Yunying Zhao and Yu Deng*. Metabolic engineering of Saccharomyces cerevisiae for efficient production of glucaric acid at high titer. Microbial Cell factories, 2018, 17:67. (IF = 4.402)

  13. Mei Zhao, Dixuan Huang, Xiaojuan Zhang, Mattheos A.G. Koffas, Jingwen Zhou, Yu Deng*. Metabolic engineering of Escherichia coli for producing adipic acid through the reverse adipate-degradation pathway. Metabolic Engineering, 2018, 47:254-262. (IF = 7.808)

  14. Yu Deng*, Ning Ma, Kangjia Zhu, Xuetuan Wei*, Yunying Zhao. Balancing the carbon flux distributions between the TCA cycle and glyoxylate shunt to produce glycolate at high yield and titer in Escherichia coli. Metabolic Engineering, 2018, 46: 28-34. (IF = 7.808)

  15. Zongsheng Zou, Yunying Zhao, Tingzhou Zhang, Jiaxing Xu, Aiyong He, Y Deng*. Efficient isolation and characterization of a cellulase hyperproducing mutant strain of Trichoderma reesei. Journal of Microbiology and Biotechnology, (2018), 28(9), 1473-1481 (IF= 1.975).

  16. Yu Deng*, Xi Zhang, Xiaojuan Zhang. Recent advances in genetic modification systems for Actinobacteria. Applied Microbiology and Biotechnology, 2017, 101(6):2217-2226. (IF= 3.67).

  17. Yu Deng*, Jia Lin, Yin Mao, Xiaojuan Zhang. Systematic analysis of an evolved Thermobifida fusca muC producing malic acid on organic and inorganic nitrogen sources. Scientific Reports, 2016, 6: 30025. (IF= 4.011).

  18. Yu Deng, Mingxue Sun , Sha Xu, Jingwen Zhou. Enhanced (S)-linalool production by fusion expression of farnesyl diphosphate synthase and linalool synthase in Saccharomyces cerevisiae. Journal of Applied Microbiology, 2016, 121, 187-195. (IF=2.683).

  19. Yu Deng*, Yin Mao, Xiaojuan Zhang. Metabolic Engineering of a laboratory-evolved Thermobifida fusca muC strain for malic acid production on cellulose and minimal treated lignocellulosic biomass. Biotechnology Progress, 2016, 32:14-20. (IF= 2.406)

  20. Yu Deng*, Yin Mao, Xiaojuan Zhang. Driving carbon flux through exogenous butyryl-CoA: Acetate CoA-transferase to produce butyric acid at high titer in Thermobifida fusca. Journal of Biotechnology, 2015, 216:151–157. (IF= 3.163)

  21. Yu Deng*, Li Zhou Ma, Yin Mao. Biological production of adipic acid from renewable substrates: current and future methods. Biochemical Engineering Journal, 2016, 105:16–26. (IF=3.371)

  22. Yu Deng*, Yin Mao, Xiaojuan Zhang. Metabolic Engineering of E. coli for Efficient Production of Glycolic Acid from Glucose. Biochemical Engineering Journal, 2015, 103: 256-262. (IF=3.371)

  23. Yu Deng*, Adam Fisher, Stephen Fong. Systematic analysis of intracellular mechanisms of propanol production in the engineered Thermobifida fusca B6 strain. Applied Microbiology and Biotechnology, 2015, 99: 8089-8100. (IF=3.67)

  24. Yu Deng*, Yin Mao. Production of adipic acid by the native-occurring pathway in Thermobifida fusca B6. Journal of Applied Microbiology, 2015, 119:1057–1063. (IF =2.683)

  25. Yu Deng*, Xiaojuan Zhang. DtxR, an iron-dependent transcriptional repressor that regulates the expression of siderophore gene clusters in Thermobifida fusca. FEMS Microbiology Letters, 2015, 362: 1–6. (IF=1.994)

  26. Kyle Merklein, Stephen Fong, Yu Deng*. Production of butyric acid by cellulolytic actinobacterium Thermobifida fusca on cellulose. Biochemical Engineering Journal, 2014, 90: 239–244. (IF=3.371)

 

二、专利情况

1. Yu Deng, Daniel Olson, Johannes Pieter van Dijken, Arthur Joseph Shaw IV, Aaron Argyros, Trisha Barrett, Nicky Caiazza, Christopher D. Herring, Stephen Rogers, Frank Agbogbo. Engineering microorganisms to increase ethanol production by metabolic redirection, WO 2013089890 A2, Jun 20, 2013.

2. 邓禹,张晓娟,毛银。一种己二酸的全生物合成方法。授权号: ZL 2015 1 0369975.6,2018-08-28

3. 邓禹,张晓娟,马宁。一种无基因敲除提高大肠杆菌中乙醇酸产率的方法。授权号:ZL 201610480579.5;2019-12-27

4. 邓禹,张晓娟,邹宗胜,周彤。一种无基因敲除提高大肠杆菌中乙醇酸产率的方法。授权号:ZL 201610399010.6,2019-08-23

5. 邓禹,赵梅,毛银,张晓娟,黄荻萱。一种提高大肠杆菌中己二酸产量的方法。授权号:ZL 201710117371.1,2020-02-18

6. 邓禹,卢伟强,张晓娟,毛银。一株快速降解污水中氮素的菌株及其应用。授权号:ZL 201710139452.1 ,2019-10-08

7. 邓禹,卢伟强,张晓娟,赵运英,毛银。一株小球藻及其在降解污水中的应用。授权号:ZL 201710565200.5 ,2019-10-08

8. 邓禹,赵梅,毛银,赵运英,卢伟强,陆春波。一种从发酵液中提取己二酸的方法。授权号:ZL 201710622975.1,2019-09-03

9. 邓禹,杨菊,张晓娟,赵运英,毛银。一种5-羰基-2-戊烯酰基辅酶A还原酶突变体。授权号:ZL 201710623724.5,2019-09-17

10. 邓禹,邹宗胜,赵运英,毛银。一株植物乳杆菌及其在发酵饲料方面的应用。授权号:ZL 201710749942.3,2019-11-19

11. 邓禹,陆春波,毛银,赵运英。一株乳酸片球菌及其应用。授权号:ZL201710585894.9,2019-09-03

12. 邓禹,陆春波,毛银,赵运英。一株副干酪乳杆菌及其应用。授权号:ZL201710585895.3,2019-09-03

 

 

三、承担教学科研项目情况

  1. 国家重点研发计划项目,活性污泥底盘细胞的设计及污染物高效降解菌的构建

  2. 国家自然科学基金-面上项目,平衡大肠杆菌代谢流量分配高效积累乙醇酸,

  3. 国家自然科学基金-青年项目,乙醇酸合成途径基因在大肠杆菌中的模块化协调表达

  4. 江苏省自然科学基金-青年项目,代谢改造大肠杆菌高效积累乙醇酸的分子机

  5. 理研究

  6. 江南大学自主科研-重点项目,代谢改造大肠杆菌高效积累葡萄糖二酸

  7. 江南大学自主科研-青年项目,理性调控大肠杆菌代谢途径高效积累乙醇酸的研究

  8. 2015年江苏特聘教授项目

  9. 2016年江苏省“双创人才”高校创新

  10. 2016年江苏省“六大人才高峰”

  11. 2017年江苏省“双创计划”-创新团队

  12. 江苏省生物质能与酶技术重点实验室开放课题

  13. 江南大学“一流学科”建设面上项目

  14. 其他企业合作项目,主要集中在生物饲料技术的开发、有机酸的发酵技术开发等。如 发酵法生产粕类发酵生产生物饲料、生物饲料关键技术的研发、己二酸技术合作研发等。

     

四、获奖情况(含指导学生获奖)

  1. 第三届全国大学生生命科学竞赛暨江苏省第一届大学生生命科学竞赛二等奖(2019,1/1)

     

     

    以上资料更新时间截止:2020年4月

 

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