赵群

职称：教授、博士生导师

学历/学位：研究生、博士

电话：

电子邮箱：qunzhao@jiangnan.edu.cn

赵群，2024年入职江南大学，任生物工程学院教授。

主要从事生物催化、酶工程以及绿色合成相关研究：基于化学/生物反应的基本原理，结合酶定向进化等分子生物学技术手段以及分子动力学模拟等计算机辅助手段，对酶的结构进行修饰和改造，实现酶的催化机制重塑和酶的催化功能拓展，创制非天然新功能酶，将非天然反应引入酶催化体系。团队致力于开发新的酶催化方法学，包括：天然酶的机制重塑与功能拓展、人工酶的构建与催化；以及绿色合成方法学。

近年来已经在Science、Nature Synthesis、Chemical Reviews、Coordination Chemistry Reviews、Angewandte Chemie International Edition 等期刊发表多篇论文。

课题组主页：https://www.x-mol.com/groups/qunzhao

2024年至今    江南大学生物工程学院，教授、博士生导师

2020−−2023 美国约翰霍普金斯大学，博士后研究员

2018−−2019 美国罗格斯大学，博士后研究员

2014−−2017 法国国立应用科学研究院/法国精细有机化学研究所，博士

Selected Publications:

(14) Zhao, Q.; Chen, Z.; Soler, J.; Rui, J.; Y.; Yang, Y.; Garcia-Borràs, M.; Huang, X. Engineering Nonhaem Iron Enzymes for Enantioselective C−F Bond Formation via Radical Fluorine Transfer. 

Nat. Synth. 2024, 3, 958-966.

(13) Zhao, Q.; Rahman, M.; Zhou, T.; Yang, S.; Szostak, M. Wingtip-Flexible N−Heterocyclic Carbenes: Unsymmetrical Connection between IMes and IPr. 

Angew. Chem. Int. Ed. 2024, e202318703.

(12) Rui, J.; Zhao, Q.; Huls, A.; Soler, J.; Paris, J.; Chen, Z.; Yang, Y.; Guo, Y.; Garcia-Borràs, M.; Huang, X. Directed Evolution Of Non-Heme Iron Enzymes to Access Abiological Radical-Relay C(sp³)−H Azidation. 

Science 2022, 376, 869-874.

(11) Zhao, Q.; Li., G.; Lalancette, R.; Szostak, R.; Szostak, M. Structures of the Most Twisted Thioamide and Selenoamide: Effect of Higher Chalcogens of Twisted Amides on N–C(X) Resonance. 

Angew. Chem. Int. Ed. 2022, e202207346.

(10) Zhang, J.; Liu, J.; Ma, Y.; Fang, R.; Zhao, Q (Co-Corresponding).; Szostak, M. Ruthenium-Catalyzed C–F Bond Arylation of Polyfluoroarenes: Polyfluorinated Biaryls by Integrated C–F/C–H Functionalization. 

ACS. Catal. 2022, 12, 14337-14346.

(09) Zhao, Q.; Meng, G.; Li., G.; Flach, C.; Szostak, M. IPr^#–Highly Hindered, Broadly Applicable N–Heterocyclic Carbenes. 

Chem. Sci. 2021, 12, 10583-10589.

(08) Zhao, Q.; Meng G.; Nolan S P.; Szostak M. N−Heterocyclic Carbene Complexes in C-H Activation Reactions. 

Chem. Rev. 2020, 120, 1981-2048.

(07) Zhao, Q.; Lalancette R A.; Szostak R.; Szostak M. Ring-Opening Olefin Metathesis of Twisted Amides: Activation of Amide Bonds by C=C Cleavage. 

ACS. Catal. 2020, 10, 737-742.

(06) Zhao, Q.; Zhang, J.; Szostak M. Ruthenium(0)-Catalyzed Cross-Coupling of Anilines with Organoboranes by Selective Carbon-Nitrogen Cleavage. 

ACS. Catal. 2019, 9, 8171-8177.

(05) Zhao, Q.; Szostak M. Redox-Neutral Decarbonylative Cross‐Couplings Coming of Age. 

ChemSusChem 2019, 12, 2983-2987.

(04) Zhao, Q.; Zhang, J.; Szostak M. Ruthenium(0)-Sequential Catalysis for the Synthesis of Sterically Hindered Amines by C-H Arylation/Hydrosilylation.

Chem. Commun. 2019, 55, 9003-9006. 

(03) Zhao, Q.; Vuong, T. M. H.; Bai, X. F.; Pannecoucke, X.; Xu, L. W.; Bouillon, J. P.; Jubault, P. Catalytic Enantioselective Synthesis of Highly Functionalized Pentafluorosulfanylated Pyrrolidines. 

Chem. Eur. J. 2018, 24, 5644-5651.

(02) Zhao, Q.; Poisson, T.; Pannecoucke, X.; Bouillon, J. P.; Besset, T. Poisson, T.; Pannecoucke, X.; Bouillon, J. P.; Besset, T. Pd-Catalyzed Diastereoselective Trifluoromethylthiolation of Functionalized Acrylamides.

Org. Lett. 2017, 19, 5106-5109. 

(01) Zhao, Q.; Tognetti, V.; Joubert, L.; Besset, T.; Pannecoucke, X.; Bouillon, J. P.; Poisson, T. Palladium-Catalyzed Synthesis of 3-Trifluoromethyl-Substituted 1,3-Butadienes by Means of Directed C-H Bond Functionalization. 

Org. Lett. 2017, 19, 2106-2109.

Patents:

(5) Michal Szostak; Qun, Zhao; Md Mahbubur Rahman. Unsymmetrical N-heterocyclic carbene catalysts and methods using same. 

2024-06-06, 美国, US18/278,947

(4) Michal Szostak; Qun, Zhao; Guangrong MENG; Guangchen Li. Ligands for transition metal catalysts. 

2023-03-30, 美国, US17/791,673  

(3) Xiongyi, Huang; Anthony J. Huls; Qun, Zhao; Jinyan, Rui; Zhenhong, Chen; James, Zhang. Biocatalytic use of nonheme iron proteins for molecular functionalization. 

2023-11-23, WIPO, PCT/US2023/022431 

(2) 雷新胜; 林国强.(院士); 赵群; 许千千; 单广胜. Natural product fructus psoraleae phenol and asymmetric synthesis method of enantiomer thereof. 

2017-10-10, 中国, CN201310401426.3 

(1) 雷新胜; 林国强.(院士); 许千千; 赵群. Asymmetric synthesis method for delta³-2-hydroxybakuchiol and analog compounds.

 2016-09-07, 中国, CN201310330679.6 

Commercialization with Sigma-Aldrich®:

Full Publication list：

https://scholar.google.com/citations?user=0J4YL10AAAAJ&hl=zh-CN

课题组主页：

https://www.x-mol.com/groups/qunzhao

以上成果更新至 2025年12月