胡宝东

职称：助理研究员

学历/学位：研究生/博士

电话：

电子邮箱：hubaodong@jiangnan.edu.cn

主要从事合成生物学与代谢工程基础及应用研究,包括P450酶异源表达、分子改造与催化应用开发,以及植物天然产物微生物细胞工厂创制。已在Angewandte Chemie International Edition、Advanced Science、ACS Synthetic Biology等期刊发表SCI论文14篇;申请发明专利3项;主持国家自然科学基金青年科学基金项目(C类)、江苏省自然科学基金青年项目,参与国家重点研发计划、江苏省前沿技术研发计划等多项国家级、省部级科研项目。

2009.09-2013.06  淮北师范大学,生物科学专业,学士

2013.09-2016.06  贵州大学,发酵工程专业,硕士

2016.08-2017.07  贵州省天然产物研究中心,研究实习员

2018.08-2023.06  江南大学,发酵工程专业,博士

2023.07-2026.06  江南大学,未来食品科学中心,博士后

2026.07至今        江南大学,未来食品科学中心,助理研究员

主要代表性成果:

一、论文(论著)发表情况

1、Baodong Hu, Haibo Yu, Jingwen Zhou, Jianghua Li, Jian Chen, Guocheng Du,  Sang Yup Lee, and Xinrui Zhao*, Whole-cell P450 biocatalysis using engineered Escherichia coli with fine-tuned heme biosynthesis. Advanced Science, 2023, 10(6): 2205580. 

2、Ding Luo#, Huining Ji#, Baodong Hu#, Jinxing Cai#, Kaiqi Wen, Xiaoyang Qu, Mingfeng Cao, Xinrui Zhao*, Binju Wang*, A multimodal ensemble framework for optimal mutant prediction and computational enzyme engineering. Angewandte Chemie International Edition. 2026, 65 (6), e21396.

3、Baodong Hu, Xinrui Zhao*, Endao Wang, Jingwen Zhou, Jianghua Li, Jian Chen,  Guocheng Du*, Efficient heterologous expression of cytochrome P450 enzymes in microorganisms for the biosynthesis of natural products. Critical Reviews in Biotechnology, 2023,43(2): 227-241.

4、Baodong Hu, Jingwen Zhou, Jianghua Li, Jian Chen, Guocheng Du, Fang Zhong, Yucheng Zhao*, Xinrui Zhao*, Efficient biosynthesis of furanocoumarin intermediate marmesin by engineered Escherichia coli. ACS Synthetic Biology, 2025, 14 (3), 954-966.

5、Baodong Hu†, Cuiping Pang †, Ding Luo†, Yongchao Wang †, Chixiang Sun †, Jingwen Zhou, Jian Chen, Guocheng Du, Fang Zhong, Jiahai Zhou*, Binju Wang*, and Xinrui Zhao*, Improved catalytic efficiency of P450 OleP for converting lithocholic acid into murideoxycholic and ursodeoxycholic acids through semi-rational and rational design. Synthetic and Systems Biotechnology. 2027, 15, 94-104.

6、Baodong Hu, Xinrui Zhao*, Jingwen Zhou, Jianghua Li, Jian Chen, Guocheng Du*, Efficient hydroxylation of flavonoids by using whole-cell P450 sca-2 biocatalyst in Escherichia coli. Frontiers in Bioengineering and Biotechnology, 2023,11: 1138376.

7、Dejun Wan, Baodong Hu*, Jingwen Zhou, Jianghua Li, Jian Chen, Guocheng Du, and Xinrui Zhao*, Efffcient biosynthesis of serotonin and melatonin through combinatorial metabolic engineering in Escherichia coli. Food Bioscience. 2026, 79, 108730.

8、Jiayi Luo, Baodong Hu*, Jingwen Zhou, Jianghua Li, Jian Chen, Guocheng Du, and Xinrui Zhao*, Efffcient Secretory expression of soybean peroxidase in Saccharomyces cerevisiae through systematic engineering. Journal of Agricultural and Food Chemistry. 2026, 774 (17), 13876-13886.

9、LiPing Wang, ChiXiang Sun, Baodong Hu*, Xinrui Zhao*, Recent advances in P450 enzyme engineering for the production of natural products. ChemBioChem 2025, 26 (19), e202500585.

10、Zihan Zhang#, Baodong Hu#, Jingwen Zhou, Jianghua Li, Jian Chen, Guocheng Du*, Xinrui Zhao*, Construction of a plasmid-free Escherichia coli strain with enhanced heme supply to produce active hemoglobins. Metabolites, 2025, 15 (3), 151.

二、专利情况

1、赵鑫锐,胡宝东,周景文,堵国成,陈坚,李江华,利用大肠杆菌P450酶全细胞催化合成羟基化黄酮化合物的方法及应用, 2023-10-03, 中国, ZL202310079752.0

2、赵鑫锐,胡宝东,赵玉成,周景文,堵国成,陈坚,李江华,一种高效合成呋喃香豆素异紫花前胡内酯重组大肠杆菌,专利申请号:2025102111399

3、赵鑫锐,万德军,胡宝东,周景文,堵国成,陈坚,李江华,一种提升大肠杆菌合成血清素和褪黑素的方法及应用,专利申请号:2026102028199

三、承担教学科研项目情况

1、国家自然科学基金青年科学基金项目(C类)(22508141) 2026.01-2028.12, 项目负责人

2、江苏省自然科学基金青年项目(BK20251598) 2025.09-2028.08, 项目负责人

3、国家重点研发计划(2025YFF1108200).2025.12-2028.11, 任务负责人

4、江苏省前沿技术研发计划(现代农业)(BF2025318) 2025.07-2029.06, 任务负责人

以上资料更新时间截止:2026年8月