王蕾

职称：助理研究员

学历/学位：研究生/博士

电话：15961803735

电子邮箱：leiwang_enzyme@jiangnan.edu.cn

长期从事系统代谢工程与合成生物学的研究，主要承担《微生物代谢工程》、《细胞工程》和《有机酸工艺学》课程的讲授工作。近五年在Nature Catalysis、Nature Communications、Metabolic Engineering、Chemical Reviews、Trends in Biotechnology等期刊上发表SCI 论文30余篇；授权发明专利20余项；主持国家重点研发计划(课题、子课题)、国家自然科学基金(优青、面上、青年)、江苏省自然科学基金(杰青、青年)等国家级及省部级科研项目10余项；获得教育部科技进步一等奖(2015，2/5)、江苏省科学技术奖二等奖(2021，2/8)、闵恩泽能源化工奖(青年进步奖)、江苏省优秀博士学位论文。

2006.09-2010.06   聊城大学，生命科学学院，生物工程专业，学士

2010.09-2015.06   江南大学，生物工程学院，发酵工程专业，博士

2015.06-2017.06   江南大学，食品科学与技术国家重点实验室，讲师

2019.08-2020.09   美国加州大学伯克利分校，劳伦斯伯克利国家实验室，访问学者

2021.06-至今        江南大学，食品科学与技术国家重点实验室、生物工程学院，助理研究员

1. Deming Rao, Runtian Huo, Zhengfei Yan, Zhiyong Guo, Weiqiong Liu, Mengwei Lu, Hui Luo, Xiumei Tao, Weikang Yang, Lingqia Su, Sheng Chen, Lei Wang*, Jing Wu*. Multiple approaches of loop region modification for thermostability improvement of 4,6-α-glucanotransferase from Limosilactobacillus fermentum NCC 3057. International Journal of Biological Macromolecules, 2023,233(1): 123536

2. Xiumei Tao, Lingqia Su, Sheng Chen, Lei Wang*, Jing Wu*. Producing 2-O-α-D-glucopyranosyl-L-ascorbic acid by modified cyclodextrin glucosyltransferase and isoamylase. Applied Microbiology and Biotechnology, 2023,107,1233–1241.

3. Lei Wang, Yongmei Xia, Lingqia Su*, Jing Wu*. Modification of Bacillus clarkii γ-Cyclodextrin Glycosyltransferase and Addition of Complexing Agents to Increase γ-Cyclodextrin Production. Journal of Agricultural and Food Chemistry, 2020, 68(43):12079-12085.

4. Lei Wang, Quan Wu, Kang Zhang, Sheng Chen, Zhengfei Yan*, Jing Wu*. Cyclodextrinase from Thermococcus sp expressed in Bacillus subtilis and its application in the preparation of maltoheptaose. Microb Cell Fact, 2020,19:157. 2020.08

5. Lei Wang, Sheng Chen, Jing Wu*, Cyclodextrin enhanced the soluble expression of Bacillus clarkii γ-CGTase in Escherichia coli, BMC Biotechnology, 2018, 18: 72  2018.12

6. Lei Wang, Xuguo Duan, Jing Wu*, Enhancing the α-Cyclodextrin Specificity of Cyclodextrin Glycosyltransferase from Paenibacillus macerans by Mutagenesis Masking Subsite -7, Applied and Environmental Microbiology, 2016, 82(8): 2247-2255

7. Zhiyong Guo, Lei Wang, Lingqia Su, Sheng Chen, Wei Xia, Isabelle André, Carme Rovira,* Binju Wang,* Jing Wu*. A Single Hydrogen Bond Controls the Selectivity of Transglycosylation vs Hydrolysis in Family 13 Glycoside Hydrolases. The Journal of Physical Chemistry Letters, 2022, 13(24): 5626–5632

8. Demin Kong, Lei Wang, Xiaoqian Chen, Wei Xia, Lingqia Su, Fangyuan Zuo, Zhengfei Yan, Sheng Chen and Jing Wu*. Chemical-biological degradation of polyethylene combining Baeyer–Villiger oxidation and hydrolysis reaction of cutinase. Green Chemistry. 2022, 24(5): 2203-2211. 

9. Xiaoqian Chen#, Zhiyong Guo#, Lei Wang#, Zhengfei Yan#, Changxu Jin, Qingsong Huang, Demin Kong, Demin Rao, Jing Wu*. Directional-path modification strategy enhances PET hydrolase catalysis of plastic degradation. Journal of Hazardous Materials. 2022, 433, 128816. 

10. HuiZhang#, DeminKong#, LeiWang, WeiXia, CongyuYao, JingWu*. Degradation of UV-pretreated polyolefins by latex clearing protein from Streptomyces sp. Strain K30. Science of The Total Environment. 2022, 806 (Pt 4), 150779. 2021.10.05