孙付保

职称：教授/博导，PI

学历/学位：研究生/博士

电话：

电子邮箱：sunfubao@126.com

江南大学至善岗位教授，江苏省“333高层次人才”和 “六大人才高峰” 等政府荣誉，以及“桑麻”学者、“杜邦”学者、“蔚蓝生物”学者等社会荣誉获得者。作为项目首席，承担国家重点研发计划国合专项和国家自然科学基金（联合）重点；作为生物资源与生物炼制研究团队负责人，带领团队长期从事生物炼制、发酵工程、酶工程、代谢工程和合成生物学等方面的科研教学工作；团队成员包括：孙驰贺副研究员、Meysam Madadi副研究员和胡芸实验师。

团队近5年承担国家重点研发计划重点专项课题、国家重点研发计划国际合作专项、国家自然科学基金重点（联合）/国际合作/面上/青年等省部级以上科研项目20余项，以及企业委托项目10余项；授权国家发明专利20余件（含美国专利2件）、发表高水平论文120余篇；获得广西壮族自治区技术发明一等奖等省部级奖励6项；团队负责人为国际杂志J Chem Technol Biotechnol编委（2013-）、Advances in Environmental Technology编委（2023-）、Current Nutrition& Food Science 编委(2025-)、中国生物工程学会会员和生物质能专委会委员。

团队研究方向

1）酶工程、代谢工程和合成生物学

大健康功能性配料的绿色生物制造，具体包括：饲用抗生素、萜烯类化合物和高附加值氨基酸等生产菌种选育、微生物酶改造、代谢合成途径分析、发酵过程优化与控制等。

2）生物炼制

围绕国家“双碳”战略，开展生物基化学品/能源/材料先进生物制造的理论创新和技术升级，具体包括：农林生物质原料组成结构的绿色高效拆解；微生物酶挖掘和迭代进化改造；多碳源抗逆性共发酵工程菌的合成生物学改造；酶解糖化 / 发酵过程的AI辅助优化与智能性控制。

2001.9-2004.4：大连工业大学，发酵工程，硕士

2004.9-2008.9：中国科学院过程工程研究所，生物化工，博士

2009.1-2012.9：江南大学生物工程学院，讲师

2012.5-2019.5：江南大学生物工程学院，副教授，硕士生导师

2019.6-现在：江南大学生物工程学院教授，博士生导师

其中：

2012.5-2013.5：加拿大不列颠哥伦比亚大学(UBC)，博士后

2016.7-2016.9：明尼苏达大学(UMN)，访问学者

一、论文（论著）发表情况

团队近5年以通讯或一作在Nature foods, Adv. Sci., Biotechnol. Adv., Chem. Eng. J., Green Chem.等发表SCI研究论文100余篇，代表性文章如下：

2026年

1）酶工程、代谢工程部分

[1]Haobo Xing, Qingming Hou, Zhenhua Wang, Shanfei Zhang*, Shangxia Song, Lulu Du, Chenghua Gao, Yunfei Li, Fubao Sun*. Overexpression of new genes in Streptomyces cinnamonensis for efficient monensin biosynthesis with a multi-module collaborative strategy. Biochemical Engineering Journal 230 (2026) 110118

[2] Xiaotong Kang, Hang Yuan, Weimeng Li, Yun Hu *, Fubao Sun *. Enhanced activity and stability of thermostable endoglucanase Dictyoglomus turgidum DtCelA with multiple strategies. Enzyme and Microbial Technology 195 (2026) 110809

2）生物炼制部分

[3] Salauddin Al Azad, Ehsan Kargaran, Maryam Saleknezhad, Yuanchao Cheng, Conghui Quan, Junyao Chen, Chihe Sun, Meysam Madadi *, Fubao Sun *. Choline chloride enables low-severity NaOH/Triton-X 100pretreatment and lignin upgradingto enriched aromatic bio-oil andporous biochar. Chemical Engineering Journal, DOI: 10.1016/j.cej.2026.176853 (2026)

[4] Meysam Madadi *, Zicheng Liu, Salauddin Al Azad, Ehsan Kargaran, Chihe Sun, Vijai Kumar Gupta & Fubao Sun *. Amino-acid interface engineering of lignin for functional carbon production and reinforced 3D‑printed PLA composites. Advanced Composites and Hybrid Materials‌, DOI: 10.1007/s42114-026-01796-6 (2026)

2025年

1）微生物酶工程、代谢工程部分

[1] Zhang, Shanfei, Qingming Hou, Zhenhua Wang, Xianyuan Zhang, Dandan Tian, Yan Zhang, Dandan Wang, Ning Chen, Fubao Sun*. Enhanced monensin production via co-fermentation of lignocellulosic hydrolysate using mutated streptomyces cinnamonensis. Industrial Crops and Products, 2025, 230: 121119.

[2] Weimeng Li, Hang Yuan, Yun Hu*, Shaohua Dou, Ezhen Zhang*, QunWu, Fubao Sun*. Construction of new thermostable MtLPMO9V in synergism with cellulases for efficient lignocellulosic hydrolysis. Bioresource Technology, (2025): 132594.

[3] Hang Yuan, Samaila Boyi Ajeje, Yunzhe Wen, Chonlong Chio, Yun Hu, Shaohua Dou, Wensheng Qin, Ezhen Zhang, Qun Wu, Fubao Sun*. Enhancement of the catalytic activity of thermostable Endo-1, 4-β-glucanase B (TnCelB) from Thermotoga neapolitana by error-prone PCR. International Journal of Biological Macromolecules, 2025, 308: 142310.

[4] Qiangqiang Liu, Meysam Madadi, Salauddin Al Azad, Xingmei Lu, Hong Yan, Qing Zhou, Chihe Sun*, Fubao Sun*. Unveiling the mechanisms of mixed surfactant synergy in passivating lignin-cellulase interactions during lignocellulosic saccharification. Journal of Colloid and Interface Science, 2025, 681: 404-415.

[5] Qiangqiang Liu, Chihe Sun, Meysam Madadi*, Ezhen Zhang, Ao Xia, Abdolreza Samimi, Fubao Sun*. Elucidation of mixed surfactants reducing mass transfer resistance during high-solids enzymatic hydrolysis from lignocellulosic biomass. Chemical Engineering Journal, 2025, 507: 160332.

[6] Shanfei Zhang, Zhenhua Wang, Dandan Tian, Yan Zhang, Chihe Sun, Qingming Hou, Jingle Liang *, Qun Wu, Fubao Sun *. Effect of exogenous addition of fatty acids on the production of monensin from Streptomyces cinnamonensis fermentation.  Process Biochemistry, 2025, 156: 350-358

[7] Zhang, Shanfei, Qingming Hou, Zhenhua Wang, Xianyuan Zhang, Dandan Tian, Yan Zhang, Dandan Wang, Ning Chen, Fubao Sun*. Enhanced monensin production via co-fermentation of lignocellulosic hydrolysate using mutated streptomyces cinnamonensis. Industrial Crops and Products, 2025, 230: 121119.

[8] Shanfei Zhang, Zhenhua Wang, Qingming Hou, Xianyuan Zhang, Dandan Tian, Yan Zhang, Qun Wu, Fubao Sun*. Identification of specific genes related to efficient Monensin biosynthesis in Streptomyces cinnamonensis with genomic analysis. Systems Microbiology and Biomanufacturing, 2025: 1-11.

[9] Shanfei Zhang, Qingming Hou, Zhenhua Wang, Dandan Tian, Xianyuan Zhang, Yan Zhang, Qun Wu, Fubao Sun*. Fatty acid addition strategy redirected the metabolic flux towards an ultra-high monensin productivity of Streptomyces cinnamonensis. Synthetic and Systems Biotechnology, 2025, 10(2): 532-542.

2）生物炼制部分

[10] Meysam Madadi*, Hamid Amiri, Junting Pan, Guojie Song, Dan Liu, Vijai Kumar Gupta*, Mortaza Aghbashlo, Meisam Tabatabaei. "Food loss and waste valorization offers a sustainable source of biopolymers in bioinks for 3D printing." Nature Food, 2025: 1-8.

[11] Guojie Song, Peng Teng, Meysam Madadi*, Hadiyanto Hadiyanto, Chihe Sun*, Jinguang Hu, Fubao Sun*. "Fabrication of lignin-containing cellulose nanofibrils with unique properties via a simple PEG-assisted strategy." Carbohydrate Polymers, 2025, 370, 124363.

[12] Guojie Song, Salauddin Al Azad, Wenhao Hu, Meysam Madadi, Ashfaque Rahman, Chihe Sun, Fubao Sun. "Comparison study and mechanisms insight of AlCl3-catalyzed different organosolv pretreatment of lignocellulose: Enhancing enzymatic hydrolysis, lignin fractionation, and furfural production." Bioresource Technology, 2026, 439, 133308.

[13] Meysam Madadi, Mahdy Elsayed, Guojie Song, Razieh Shafiei-Alavijeh, Joeri F. Denayer, Ehsan Kargaran, Salauddin Al Azad, Keikhosro Karimi *, Fubao Sun *, Vijai Kumar Gupta *. "Transformative biorefinery model for biomass valorization into biofuel and renewable platform chemicals." Journal of Energy Chemistry, 2025, 110: 109-123.

[14] Guojie Song, Wenhao Hu, Ezhen Zhang, Vijai Kumar Gupta, Qun Wu, Meysam Madadi*, Chihe Sun, Fubao Sun*. "Polyethylene glycol-driven lignin-first biorefinery: A pathway for efficient conversion of lignocellulose to ethanol, furfural, and lignin-derived solid electrolytes." Chemical Engineering Journal 515 (2025) 163530

[15] Meysam Madadi, Ehsan Kargaran, Seyed Sajad Hashemi, Chihe Sun, Joeri FM Denayer, Keikhosro Karimi*, Fubao Sun*, Vijai Kumar Gupta*. "Scalable Lignin Monomer Production via Machine Learning-Guided Reductive Catalytic Fractionation of Lignocellulose." Advanced Science, 2025: e10496.

[16] Guojie Song, Dan Liu, Meysam Madadi*, Caiyue Li, Liang Liu, Chihe Sun*, Ezhen Zhang, Alireza Ashori, Fubao Sun*. "Surfactant-aided acid glycerol pretreatment of sugarcane bagasse: Dual benefits of substrate and lignin modifications for improved enzymatic hydrolysis." Energy, 2025, 320: 135520

[17] Yuting Tan, Meysam Madadi*, Guojie Song, Chihe Sun, Mahdy Elsayed, Fubao Sun*, Vijai Kumar Gupta*. "Integrated biorefinery routes to transform furfural waste into 2G biofuels and PFOA-adsorbing biochar." Green Chemistry, 2025, 27(13): 3573-3589.

[18] Hui Zhang, Weimeng Li, Guojie Song, Salauddin Al Azad, Meysam Madadi, Zhichao Deng, Abdolreza Samimi, Chihe Sun*, Fubao Sun*. "Role of in situ surfactant modification of lignin structure and surface properties during glycerol pretreatment in modulating cellulase-lignin binding affinities." Journal of Colloid and Interface Science, 2025, 687: 786-800.

2024年

[19] Chihe Sun, Huan Chen, Meysam Madadia, Guojie Song, Xianzhi Meng, Xinshu Zhuang, Xueping Song, Xuesong Tan, Fubao Sun*, Arthur J.Ragauskas. Understanding the role of porous particle characteristics and water state distribution at multi-scale variation on cellulase hydrolysis of lignocellulosic biomass. Energy 2024, 310: 133263

[20] Guojie Song, Hui Zhang, Meysam Madadi, Zhixiangpeng Chen, Hao Wang, Ao Xia, Abdolreza Samimi, Chihe Sun*, Xianzhi Meng, Arthur J. Ragauskas, Fubao Sun. Unraveling the secrets of harnessing surfactant-modified strategy in organosolv pretreatment of lignocellulosic biomass for efficient fermentable sugar production. Green Chemistry 2024,26: 10123-10138

[21] Guojie Song, Liang Liu, Meysam Madadi*, Mahdy Elsayed*, Chihe Sun, Qiangqing Liu, Junhui Zhang, Fubao Sun, Alireza Ashori. Integrated approach for co-production of bioethanol and light aromatics from lignocellulose through polyethylene glycol-aided acidic glycerol pretreatment. Energy Conversion and Management 2024, 319: 118896

[22] Qiangqiang Liu, Chihe Sun, Meysam Madadi, Shaohua Dou, Junshu Yan, Hailin Huan, Abdolreza Samimi, Alireza Ashori, Fubao Sun*. Enhanced enzymatic hydrolysis of lignocellulosic substrate with less-expensive formulation of homemade cellulase cocktails. Industrial Crops and Products 2024, 219: 119039

[23] Chihe Sun, Hui Zhang, Meysam Madadi, Hongyan Ren, Hao Chen, Xinshu Zhuang, Xuesong Tan, Fubao Sun*. Quantitative correlation analysis between particle liquefaction and saccharification through dynamic changes of slurry rheological behavior and particle characteristics during high-solid enzymatic hydrolysis of sugarcane bagasse. Bioresource Technology, 2024, 399: 130518

[24] Salauddin Al Azad, Meysam Madadi,* Guojie Song, Chihe Sun, Fubao Sun.* New trends in microbial lipid-based biorefinery for fermentative bioenergy production from lignocellulosic biomass. Biofuel Research Journal 2024,11: 2040-2064

[25] Guojie Song, Meysam Madadi, Xianzhi Meng, Chihe Sun*, Mortaza Aghbashlo, Fubao Sun*, Arthur J. Ragauskas, Meisam Tabatabaei, Alireza Ashori*. Double in-situ lignin modification in surfactant-assisted glycerol organosolv pretreatment of sugarcane bagasse towards efficient enzymatic hydrolysis. Chemical Engineering Journal 2024, 481: 148713

[26] Guojie Song, Chihe Sun, Meysam Madadi,* Shaohua Dou, Junshu Yan, Hailin Huan, Mortaza Aghbashlo, Meisam Tabatabaei, Fubao Sun,* Alireza Ashori. Dual assistance of surfactants in glycerol organosolv pretreatment and enzymatic hydrolysis of lignocellulosic biomass for bioethanol production. Bioresource Technology 2024,395: 130358

二、专利情况

团队近5年申报发明专利30余件（国际2件），授权发明专利20余件（国际2件），部分代表性授权专利如下：

[1] Oleaginous Yeast and its application, 17/674，913

[2] Method for co-production and processing of biological energy source by oil crops. US10,907,114 B2, 2021-02-02

[3] 一种从农林生物质原料中提纯木质素的方法授权号：ZL 202010583883.9

[4] 一种农林生物质原料浓醪水解产糖的方法. ZL 201710037261.4

[5] 一种强化农林生物质原料浓醪酶解产糖的方法. ZL2019104673484

[6] 油料作物联产加工生物能源的方法. ZL2016112567017

[7] 一种通过分批补料半同糖化浓醪发酵纤维素乙醇的方法. ZL 201610265845.2

[8] 一种利用太湖蓝藻的新方法. ZL 201410499839.4

[9] 一种利用烟道气爆破生物质废弃物制备固体燃料的方法. ZL201410497307.7.

[10] 一种产油酵母及其应用. ZL 2020105463630

[11] 一种高价值活性寡肽的制备方法. ZL 202110651889.X

[12] 一种高效吸附脱芳的改性活性炭及其制备方法. ZL2019100851321

[13] 一种发酵法高效制备低苦味抗氧化玉米低聚肽的方法. ZL2019100787185

[14] 一种产反式-4-羟脯氨酸重组大肠杆菌的单菌落琼脂块筛选方法. ZL 201510254026.3

[15] 一种酶活提高的酰基转移酶突变体. ZL 2023115599490

[16] 一株肉桂链霉菌、菌剂、合成莫能菌素的方法及应用. ZL 202411874857.6

[17] 一种生产N-乙酰基-反式-4-羟基脯氨酸的工程菌及应用. ZL 2023116128540

[18] 一种酰基转移酶突变体及其在 N-乙酰基-反式-4-羟基脯氨酸合成中的应用. ZL 202411990790.2

[19] 一种具有高乙酰化活性的酰基转移酶突变体及其应用ZL 2024119907851

[20] 一种全细胞催化合成N-乙酰基-反式-4-羟基脯氨酸的方法. ZL 2023115529623

三、承担科研项目情况（近5年）

团队近5年承担省部级以上项目近20余项和企业委托项目近10项，代表性项目如下：

[1] 孙付保，国家重点研发计划-合成生物学”应急项目(2025YFA0921200)：木质素生物转化制备高值化学品， 子课题

[2] 孙付保，国家重点研发2030重大专项（2025ZD0614600）：秸秆基聚乳酸关键技术开发与应用， 子课题

[3] 孙驰贺，国家自然科学基金面上项目(22478154)：溶剂/助剂双重原位修饰同步调控木质素缩合抑制及纤维质酶解增效的机理研究

[4] 孙付保，国家自然科学基金-区域创新发展联合基金重点支持项目（U23A20135），秸秆生物质组分高效拆解及定向转化基础研究

[5] 孙付保，国家自然科学基金-国际合作研究项目(22361142705)，木质纤维素基生态环境材料深度处理印染废水的基础研究

[6] Meysam Madadi，国基海外学者青年项目（22350410382），A study on the mechanism of plant proteins' amino acids for boosting enzymatic saccharification of lignocellulosic biomass

[7] 孙付保，国家重点研发计划-绿色生物制造专项课题（2022YFC2104601）：生物质预处理及高效水解糖化技术

[8] 孙付保，国家自然科学基金面上项目（22278189）：甘油有机溶剂预处理木质纤维素过程中组分甘油修饰机理及其调控

[9] 孙驰贺，国家重点研发计划-政府间国际科技创新合作重点专项课题（2021YFE0114400）：生物燃料及生物炼制中心—甘蔗渣制备生物燃料联产化学品关键技术研究

[10] 孙驰贺，国家自然科学基金青年项目(52106245)：木质纤维素类生物质浓醪糖化物质传递与酶生化转化机理及特性研究

[11] 孙付保，国家重点研发计划-政府间国际科技创新合作重点专项（2019YFE0114600）：农林生物质“三大素”的常压甘油相有效拆分及其精炼型增值转化

四、获奖情况（含指导学生获奖）

[1]广西壮族自治区技术发明一等奖（2022，第2）

[2]胡芸，孙付保. 全国大学生生命科学竞赛（2021，科学探究类）江苏赛区三等奖；

[3]高等教育国家级教学成果二等奖（2018，第9）；

[4]中商联科技进步一等奖（2016，第1）；

[5]湖南省科技进步二等奖（2016，第3）；

[6]海南省科技进步三等奖（2017，第3）

以上资料更新时间截止：2026年5月